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CRBP I and CRABP I localisation during olfactory nerve development.

A L Gustafson1, U Eriksson, L Dencker

  • 1Department of Pharmaceutical Bioscience, Division of Toxicology, Uppsala Biomedical Centre, Uppsala University, Box 594, 751 24, Uppsala, Sweden. annelee.gustafson@tox.uu.se

Brain Research. Developmental Brain Research
|April 21, 1999
PubMed
Summary

Retinoic acid (RA) is crucial for olfactory system development. Specialized cells expressing binding proteins produce RA, potentially supporting immature olfactory neuron growth.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Retinoic acid (RA) is implicated in nervous system development.
  • The precise role of RA in olfactory system formation requires further elucidation.

Purpose of the Study:

  • To investigate the localization and potential role of retinoid-binding proteins in the developing and adult olfactory system.
  • To explore the neurotrophic function of retinoic acid in olfactory axon development.

Main Methods:

  • Immunohistochemistry was employed to detect cellular retinol-binding protein I (CRBP I) and cellular retinoic acid-binding protein I (CRABP I).
  • Localization studies were performed on both embryonic and adult olfactory system tissues.

Main Results:

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  • CRBP I and CRABP I were localized within the olfactory system.
  • CRBP I-expressing cells, identified as 'glia-like' cells, were found to produce RA.
  • Immature olfactory axons expressing CRABP I were observed.

Conclusions:

  • Retinoic acid, produced by glia-like cells, may function as a neurotrophic factor.
  • RA signaling, mediated by CRBP I and CRABP I, appears to support the development of olfactory axons.