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Updated: Aug 10, 2026

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
[Recurrent subacute encephalopathy in the framework of idiopathic hypereosinophilic syndrome]
B Balestra1, P Pedrazzi, F Regli
1Medizinische Abteilung, Ospedale della Beata Vergine, Mendrisio.
History:
An 81-year-old man, previously good health, suddenly developed confusion and rapidly progressive severe tetraparesis.
Investigations:
Peripheral blood and bone marrow revealed marked eosinophilia: allergic, parasitic, neoplastic or vasculitic causes were excluded. Magnetic resonance imaging demonstrated multiple lesions in the cortical and subcortical white matter.
Diagnosis, Treatment And Course:
The findings indicated idiopathic hypereosinophilic syndrome involving the central nervous system and treatment with high doses of glucocorticoids was started. After a stormy course almost complete recovery occurred.
Conclusion:
Idiopathic hypereosinophilic syndrome can rarely manifest itself a an isolated severe subacute encephalopathy.
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