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Antihistamines in urticaria.

J Ring1, K Brockow, M Ollert

  • 1Division of Environmental Dermatology and Allergy GSF/TUM, Technische Universität München, Germany.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|April 21, 1999
PubMed
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Chronic urticaria management involves identifying triggers and using antihistamines. Mizolastine, a non-sedating H1 antagonist, effectively treats chronic urticaria, showing significant improvement over placebo.

Area of Science:

  • Dermatology
  • Allergology
  • Immunology

Background:

  • Urticaria is a common, often chronic, allergic skin disease.
  • Identifying triggers is crucial for effective management.
  • Newer concepts involve autoantibodies and Helicobacter pylori.

Purpose of the Study:

  • To review diagnostic guidelines for urticaria.
  • To discuss pathophysiological concepts including pseudo-allergic reactions.
  • To evaluate antihistamine therapy, focusing on mizolastine.

Main Methods:

  • Review of the 'three-step guideline' for trigger identification.
  • Discussion of diagnostic tests like autologous serum skin tests.
  • Evaluation of clinical trials on antihistamine efficacy, including mizolastine.

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Main Results:

  • Antihistamines, particularly H1 antagonists, are the primary treatment.
  • Combined H1/H2 antagonists may benefit specific urticaria forms.
  • Mizolastine demonstrated significant efficacy and tolerability in chronic urticaria.

Conclusions:

  • Accurate diagnosis and trigger identification are key in urticaria.
  • Antihistamines remain central to urticaria therapy.
  • Non-sedating antihistamines like mizolastine offer effective and safe treatment options.