Related Experiment Videos
Angiotropic large cell lymphoma presenting as fever of unknown origin
E Kuvliev1, T Glamour, R Shekar
1Department of Medicine, Meridia Huron Hospital, East Cleveland, Ohio 44112, USA.
Background:
Fever has never before been described as the chief complaint and major finding in angiotropic large cell lymphoma (ALCL). ALCL is a rare and usually fatal intravascular tumor characterized by a widespread proliferation of malignant mononuclear cells within vessels of small caliber, causing their blockage. The majority present as high-grade, B-cell lymphomas with a predilection for the central nervous system and the skin.
Case Report:
We report a 61-year-old woman who presented with a fever of unknown origin (FUO) that lasted 9 weeks from onset to death. To our knowledge, this is the first case of ALCL to present solely as a FUO, and the second case of ALCL to be diagnosed by muscle biopsy.
Conclusion:
We suggest that this rare malignancy (ALCL) be considered in the differential diagnosis of FUO.