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Updated: Aug 14, 2026
10:19
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Micturition after gastrocystoplasty and gastric bladder replacement
M M Koraitim1, M R Khalil, G A Ali
1Department of Urology, College of Medicine, University of Alexandria, Egypt.
The Journal of Urology
|April 21, 1999
Summary
Gastric tissue serves as an effective bladder substitute, offering increased capacity and low-pressure urine storage. This study shows stomach tissue is ideal for bladder augmentation or replacement, facilitating normal urination.
Area of Science:
- Urology
- Surgical Innovation
- Gastrointestinal Surgery
Background:
- Urinary bladder augmentation and replacement are crucial for managing conditions causing bladder dysfunction.
- Gastric tissue has been explored as a potential biomaterial for reconstructive urology due to its distensibility.
Purpose of the Study:
- To evaluate the functional capacity of gastric tissue when used for bladder augmentation (gastrocystoplasty) and total bladder replacement (gastric neobladder).
- To assess the urodynamic characteristics and voiding efficiency of patients with gastric-derived neobladders.
Main Methods:
- Twelve male patients aged 15-45 underwent either gastrocystoplasty (8 patients) or gastric bladder replacement (4 patients).
- One patient received bladder neck reconstruction with gastric augmentation.
- Follow-up included subjective and objective evaluations, with urodynamic studies performed at 6 months post-surgery.
Main Results:
- Patients experienced no dysuria or hematuria, even with acidic urine (pH ≤ 5).
- Mean bladder capacity significantly increased post-augmentation (130ml to 420ml) and was 350ml after replacement.
- Neobladders exhibited low-amplitude, late-filling involuntary contractions, with voiding primarily driven by gastric muscle contraction and abdominal straining.
Conclusions:
- Gastric tissue is a suitable material for bladder augmentation and replacement, providing a high-capacity, low-pressure reservoir.
- The inherent properties of gastric tissue, including controlled contractions, contribute to its efficacy.
- Gastric neobladders are efficiently evacuated through a combination of intrinsic muscle activity and external straining.
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