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Updated: Aug 17, 2026
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Published on: July 21, 2021
Interhemispheric interactions analyzed by coherence during flexor spasms
H Otsubo1, M Steinlin, A Shirasawa
1Department of Neurology, The Hospital for Sick Children, University of Toronto, ON, Canada. hiroshi.otsubo@mailhub.sickkids.on.ca
Objective:
We used coherence analysis to test for leading discharges on an ipsilateral right mesial temporal lesion in a 5 year old boy with flexor spasms.
Method:
Digital EEG analysis with video-EEG telemetry was performed preparatory to epilepsy surgery.
Results:
Study of 10 spasms with head drop and subsequent flexion of both arms demonstrated an interhemispheric time lag with secondary bilateral synchrony, with a mean difference of 17 ms. The right hemisphere led. After a lesionectomy with resection of epileptic regions (performed with electrocorticographical guidance), the patient has been seizure-free for 4 years. Pathology confirmed a low-grade mixed glioma and cortical dysgenesis.
Conclusion:
The coherence analysis demonstrated a pathway of secondary generalization, confirming that the lesional side was leading during ictal generalized discharges in flexor spasms.
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