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Related Experiment Videos

Screening methods for thyroid hormone disruptors.

M DeVito1, L Biegel, A Brouwer

  • 1National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

Environmental Health Perspectives
|April 22, 1999
PubMed
Summary

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This summary is machine-generated.

New EPA screening methods are needed to identify endocrine-disrupting chemicals that affect thyroid hormone function. Current methods are too specific, but rodent thyroid hormone tests show promise for broad screening.

Area of Science:

  • Environmental Science
  • Toxicology
  • Endocrinology

Background:

  • U.S. legislation mandates EPA screening for endocrine-disrupting chemicals (EDCs).
  • Workshops convened experts to discuss screening methods for thyroid hormone disruptors.
  • Focus on chemicals affecting thyroid hormone synthesis, transport, catabolism, and receptor interactions.

Framework:

  • Examined existing screening methods across vertebrate classes.
  • Identified consensus on known mechanisms of thyroid disruption (synthesis inhibition, transport alteration, increased catabolism).
  • Noted lack of evidence for direct thyroid hormone receptor activation by environmental chemicals, necessitating further research.

Implementation:

  • Proposed initial screening using rodent serum thyroid hormone levels and concurrent thyroid histology.

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  • Considered teleost (fish) models with tissue hormone production indicators.
  • Evaluated tadpole metamorphosis as a potential screen, pending validation and standardization.

    • Implications:

    • Screening methods should align with known mechanisms of thyroid hormone disruption.
    • Broad-based screening requires adaptable, validated methods beyond highly specific mechanistic assays.
    • Development of effective screening tools is crucial for regulatory assessment of EDCs.