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Long-term effect of a single dose of flunarizine in Huntington's disease
Belfiore1, Di Maio L, Napolitano
1Department of Neurology, Ospedale Civile Vito Fazzi, Lecce, Italy.
Abstract:
We report a preliminary pilot study on the clinical efficacy of flunarizine (FNZ), a calcium-entry blocker that causes extrapyramidal side-effects, in 10 patients with Huntington's disease (HD). FNZ (20 mg) administered by the sublingual route resulted in a decrease in choreic movements and improved dexterity in performing several tests. These effects lasted for at least 7 days after a single dose. Therefore, FNZ seems to exert the same effect as a long-acting neuroleptic agent in our HD patients.Copyright Lippincott-Raven Publishers
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