Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Linearity and accuracy errors in bone densitometry.

S Pors Nielsen1, O Bärenholdt, E Diessel

  • 1Hillerød Hospital, Department of Clinical Physiology, Denmark.

The British Journal of Radiology
|April 22, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of Physical Frailty: Results from the DO-HEALTH Study.

The Journal of frailty & aging·2022
Same author

Postural control is associated with muscle power in post-menopausal women with low bone mass.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
Same author

[Fatal flecainide intoxication in a 17-year-old girl].

Der Anaesthesist·2018
Same author

T2-relaxation time increases in lumbar intervertebral discs after 21d head-down tilt bed-rest.

Journal of musculoskeletal & neuronal interactions·2017
Same author

[MALT Lymphoma of the Conjunctiva in a 13-year old Child--5-Year Relapse-free Follow-up Following Antibiotic Treatment].

Klinische Monatsblatter fur Augenheilkunde·2015
Same author

[New strategies for exercise training in osteoporosis].

Der Unfallchirurg·2015
Same journal

Machine learning models using 18F-FDG PET/CT radiomics for RAS mutation prediction and prognostic stratification in colorectal cancer.

The British journal of radiology·2026
Same journal

Predictors of Relapse in Oligometastatic Prostate Patients Receiving Stereotactic Ablative Radiotherapy.

The British journal of radiology·2026
Same journal

An Evaluation of Radiotherapy and Response in the Management of Perivascular Epithelioid Cell Tumors.

The British journal of radiology·2026
Same journal

Ensuring radiology reporting quality across a national lung cancer screening programme.

The British journal of radiology·2026
Same journal

Utility of High-Resolution Semiconductor Positron Emission Tomography/Computed Tomography in the Assessment of Breast Cancer Extent: Comparison with Magnetic Resonance Imaging.

The British journal of radiology·2026
Same journal

Airway Imaging Practices in Primary Ciliary Dyskinesia: A Global Survey to Guide Standardized Guidelines.

The British journal of radiology·2026
See all related articles

Dual energy X-ray absorptiometry (DXA) devices show accuracy and linearity errors, impacting bone mineral content (BMC) and bone mineral density (BMD) measurements. These errors make comparing results between different DXA systems challenging.

Area of Science:

  • Medical Imaging
  • Bone Densitometry
  • Biomedical Engineering

Background:

  • Dual energy X-ray absorptiometry (DXA) is a standard method for assessing bone mineral content (BMC) and bone mineral density (BMD).
  • Variations in DXA device performance can affect the accuracy and reliability of osteoporosis diagnosis and monitoring.
  • Understanding instrument-specific errors is crucial for clinical interpretation and inter-system comparisons.

Purpose of the Study:

  • To quantify accuracy and linearity errors in bone densitometry using dual energy X-ray absorptiometry (DXA).
  • To identify specific sources of error in commercially available DXA instruments for planar bone measurements.

Main Methods:

  • Conducted in vitro phantom studies and in vivo investigations with human volunteers.

Related Experiment Videos

  • Evaluated commercially available bone densitometers used for planar densitometry.
  • Assessed measurements of vertebral size, bone contours, bone mineral content (BMC), bone mineral density (BMD), and projected bone area.

    • Main Results:

    • Observed significant differences in measurements of vertebral size and bone contours between instruments.
    • Identified falsely low BMC in low bone mass cases due to software omission of edge regions.
    • Noted increases in projected bone area with increasing nominal bone mass in some devices.
    • Found clinically significant accuracy errors in BMC and BMD, and substantial linearity errors in BMC measurements.
    • Demonstrated that linearity errors reduce the utility of BMC as a parameter.

    Conclusions:

    • DXA devices exhibit a combination of accuracy and linearity errors, varying by instrument.
    • Linearity errors significantly impair the ability to monitor changes in BMC and, to a lesser extent, BMD.
    • The presence of these errors complicates intercomparison between different DXA systems, affecting clinical utility.