Progressive hippocampal atrophy in chronic intractable temporal lobe epilepsy
Related Experiment Video
Updated: Oct 23, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
T J O'Brien1, E L So, F B Meyer
1Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Abstract:
We report on a 28-year-old man with long-standing intractable complex partial and secondary generalized seizures, whose magnetic resonance imaging scans 4 years apart documented progressive decrease in the left hippocampal volume. Left anterior temporal lobectomy with amygdalohippocampectomy rendered the patient seizure free at 12 months' follow-up. The findings demonstrate that patients with uncontrolled temporal lobe seizures may develop progressive atrophy of the hippocampus, in the absence of status epilepticus.
Related Concept Videos
Alzheimer Disease ll: Pathophysiology
Role of Hippocampus in Memory
Dementia l: Introduction
Alzheimer Disease l: Introduction
