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Related Experiment Videos

Subharmonic generation from ultrasonic contrast agents.

P D Krishna1, P M Shankar, V L Newhouse

  • 1School of Biomedical Engineering, Sciences and Health Systems, Drexel University, Philadelphia, PA 19104, USA.

Physics in Medicine and Biology
|April 22, 1999
PubMed
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Researchers explored subharmonic emissions from ultrasonic contrast agents. They found these microbubbles generate strong subharmonics, suggesting subharmonic imaging may improve visualization of blood vessels.

Area of Science:

  • Medical Imaging
  • Acoustics
  • Biomedical Engineering

Background:

  • Ultrasonic contrast agents enhance blood backscatter for tissue delineation.
  • Nonlinear acoustic behavior of contrast agents generates harmonic components.
  • Second-harmonic imaging is an established technique, but subharmonic emissions are less explored.

Purpose of the Study:

  • Investigate subharmonic emissions from microbubble contrast agents.
  • Assess the potential of subharmonic imaging for medical diagnostics.
  • Compare subharmonic imaging with second-harmonic imaging for blood delineation.

Main Methods:

  • Theoretical modeling of microbubble acoustic behavior.
  • Experimental validation using Optison contrast agent.

Related Experiment Videos

  • Varying microbubble surface properties and insonation conditions.

    • Main Results:

    • Microbubbles with diverse surface properties generate significant subharmonics.
    • Strong subharmonic generation observed with burst insonation at twice the resonant frequency.
    • Theoretical and experimental data confirm subharmonic emission from contrast agents.

    Conclusions:

    • Subharmonic imaging shows promise for improved blood delineation from surrounding tissue.
    • High signal-to-clutter ratio in subharmonic imaging is beneficial for deep vessel visualization.
    • Subharmonic imaging may be significant for echocardiography and vascular disease imaging.