Related Experiment Videos
Effect of gender on the pharmacokinetics of ofloxacin
K M Sowinski1, S R Abel, W R Clark
1Department of Pharmacy Practice, School of Pharmacy and Pharmacal Sciences, Purdue University, Indianapolis, Indiana 46202, USA.
Study Objectives:
To assess the influence of gender on the pharmacokinetics of ofloxacin.
Design:
Open-label study.
Setting:
Academic medical center.
Patients:
Five healthy men and seven healthy women volunteers.
Interventions:
Subjects received a single oral dose of ofloxacin 400 mg, and serial blood samples were collected for 24 hours. Plasma concentrations of ofloxacin were determined by high-performance liquid chromatography and pharmacokinetic parameters were determined. Statistical comparisons between genders were made with the Wilcoxon rank sum test.
Measurements And Main Results:
Median volume of distribution at steady state/systemic bioavailability (V(ss)/F) was significantly smaller in women than in men, although when normalized for total body weight there were no differences. Except for terminal elimination half-life, which was 10% shorter in women, no other pharmacokinetic values were significantly different between genders. Median peak concentrations, although not statistically different, were 28% higher in women.
Conclusion:
Ofloxacin V(ss)/F values were smaller in women than in men, explained by gender-related differences in weight.