Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A graphic nomogram for warfarin dosage adjustment.

G M Dalere1, R W Coleman, B L Lum

  • 1Department of Pharmacy, Kaiser Permanente Medical Center, Santa Clara, California, USA.

Pharmacotherapy
|April 22, 1999
PubMed
Summary

A graphic nomogram accurately predicts international normalized ratio (INR) for warfarin dosage adjustments, outperforming computer programs and pharmacists. This tool offers improved precision for warfarin management, especially during dosage reductions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Should Therapeutic Drug Monitoring for Monoclonal Antibodies Remain the Exception or Become the Norm?

Clinical pharmacology and therapeutics·2016
Same author

Subcutaneous versus intravenous formulation of trastuzumab for HER2-positive early breast cancer: updated results from the phase III HannaH study.

Annals of oncology : official journal of the European Society for Medical Oncology·2014
Same author

Determination of GDC-0449, a small-molecule inhibitor of the Hedgehog signaling pathway, in human plasma by solid phase extraction-liquid chromatographic-tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2010
Same author

Identifying barriers to hypertension guideline adherence using clinician feedback at the point of care.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2007
Same author

Leveraging point-of-care clinician feedback to study barriers to guideline adherence.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2006
Same author

A phase I trial of liposomal doxorubicin, paclitaxel and valspodar (PSC-833), an inhibitor of multidrug resistance.

Annals of oncology : official journal of the European Society for Medical Oncology·2005

Area of Science:

  • Pharmacology
  • Medical Informatics

Background:

  • Warfarin anticoagulation requires precise dosage adjustments to maintain therapeutic international normalized ratios (INR).
  • Accurate INR prediction is crucial for effective and safe anticoagulation therapy.

Observation:

  • A graphic nomogram was evaluated against a computer program and an anticoagulation clinic pharmacist for predicting INR values.
  • The study included 111 patients receiving warfarin therapy.

Findings:

  • The graphic nomogram demonstrated superior precision in predicting INR values compared to the computer program and pharmacist.
  • Median absolute INR prediction errors were lowest for the nomogram (0.33 overall, 0.35 for dosage reductions).
  • The nomogram was significantly more precise than both other methods (p=0.036 overall, p=0.005 for dosage reductions).

Related Experiment Videos

Implications:

  • The nomogram's precision may be clinically important for warfarin dosage adjustments, particularly for dose reductions.
  • Enhanced accuracy in warfarin management aligns with recommendations for higher-intensity therapy and higher target INR values.
  • Prospective validation in routine clinical settings is recommended to confirm the nomogram's performance.