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Related Experiment Videos

Reversible akinetic mutism possibly induced by baclofen.

D I Rubin1, E L So

  • 1Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.

Pharmacotherapy
|April 22, 1999
PubMed
Summary

A case study reports a 76-year-old man experienced akinetic mutism after low-dose baclofen. Symptoms resolved upon baclofen discontinuation, suggesting a drug-induced neurological effect.

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Baclofen is a muscle relaxant that acts on GABA-B receptors.
  • Akinetic mutism is a rare neurological condition characterized by profound apathy and lack of spontaneous movement or speech.

Observation:

  • A 76-year-old male patient developed akinetic mutism after three days of low-dose baclofen administration.
  • Electroencephalography revealed diffuse slowing and generalized sharp wave discharges.

Findings:

  • This is the first reported instance of baclofen-induced akinetic mutism in an individual with normal renal function.
  • The patient's condition fully resolved after discontinuing baclofen treatment.

Implications:

  • The findings suggest a potential neurotoxic effect of baclofen, possibly mediated by gamma-aminobutyric acid-B receptor interaction in the frontal lobes or thalamus.
  • This case highlights the importance of considering baclofen as a potential cause of akinetic mutism, even in patients with preserved kidney function.

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