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Synthesis and antitumor activities of water-soluble benzoylphenylureas
1Central Research Institute, Ishihara Sangyo Kaisha, Ltd., Shiga, Japan.
Chemical & Pharmaceutical Bulletin
|April 23, 1999
Abstract:
Water-soluble benzoylphenylurea derivatives were synthesized as candidate prodrugs and their antitumor activities were examined in vivo against P388 leukemia. Some of the prodrugs were highly soluble in water and showed good antitumor activities against P388 leukemia cells in mice when injected intravenously.