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Related Experiment Videos

The role of glial cells in synaptic function.

A Bacci1, C Verderio, E Pravettoni

  • 1CNR-Cellular and Molecular Pharmacology, University of Milano, Italy.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|April 23, 1999
PubMed
Summary

Glial cells, once thought only supportive, actively interact with neurons. This review highlights their crucial role in synapse formation, function, and plasticity within the central nervous system.

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Area of Science:

  • Neuroscience
  • Cell Biology

Background:

  • Glial cells are the most abundant cells in the central nervous system.
  • Traditionally viewed as providing only structural and trophic support to neurons.

Purpose of the Study:

  • To review recent data on the active interaction between glial cells and neurons.
  • To focus on the role of glial cells at the synapse.

Main Methods:

  • Literature review of recent studies on glia-neuron interactions.
  • Analysis of data defining glial involvement in synaptic processes.

Main Results:

  • Glial cells are determinant in synaptogenesis (the formation of synapses).
  • Glial cells actively modulate fully functional synaptic contacts.

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  • Glial cells play a significant role in synaptic plasticity.

    • Conclusions:

    • Glial cells are integral components of synaptic function and plasticity.
    • The active role of glia in neuronal communication is a key area of recent research.