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Pathobiological determinants of atherosclerosis in youth (PBDAY Study), 1986-96.

N H Sternby1, J E Fernandez-Britto, P Nordet

  • 1Department of Pathology, University of Lund, Sweden.

Bulletin of the World Health Organization
|April 23, 1999
PubMed
Summary

Atherosclerosis, or hardening of the arteries, begins in youth. The WHO/ISFC Pathobiological Determinants of Atherosclerosis in Youth (PBDAY) study found lesions develop early, influenced by lifestyle and risk factors.

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Area of Science:

  • Cardiovascular Research
  • Public Health
  • Pathology

Background:

  • Atherosclerosis is a major global health concern.
  • Early detection and intervention are crucial for cardiovascular disease prevention.
  • Understanding the determinants of atherosclerosis in youth is vital.

Purpose of the Study:

  • To investigate the pathobiological determinants of atherosclerosis in youth.
  • To analyze the progression of arterial changes from early life.
  • To compare these determinants across diverse global populations.

Main Methods:

  • 10-year multinational collaborative study (WHO/ISFC PBDAY Study).
  • Involved 18 centers in 15 countries (pilot) and 11 centers in 11 countries (main study).
  • Utilized epidemiological data, case information, and specialized arterial morphometric techniques.

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Main Results:

  • Atherosclerotic lesions initiate early in life, irrespective of race, sex, or origin.
  • Fatty streak development peaks between ages 15-25; raised lesions emerge in the second decade.
  • Prevalence and extent of lesions correlate with known risk factors and cardiovascular mortality rates.

Conclusions:

  • Atherosclerosis development is a continuous process starting in childhood.
  • Lifestyle and environmental factors significantly influence lesion progression.
  • Global disparities in atherosclerosis reflect varying risk factor prevalence.