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Environmentally responsive mutator systems: toward a unifying perspective.

M M Lieber

    Rivista Di Biologia
    |April 23, 1999
    PubMed
    Summary
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    Genetically controlled mutator processes, responsive to stress, may unify biology. These directed mutation systems across organisms suggest a universal ordering principle governing adaptation and evolution.

    Area of Science:

    • Evolutionary Biology
    • Genetics
    • Theoretical Biology

    Background:

    • Biology seeks a unifying principle to explain life's complexity.
    • Genetically controlled mutator processes, observed across diverse organisms, exhibit adaptive responses to environmental stress.
    • These systems have played a crucial role in organismal evolution.

    Purpose of the Study:

    • To explore the potential of stress-responsive mutator processes as a unifying principle in biology.
    • To investigate the deeper parameters, including forces and configurations, underlying directed mutation.
    • To examine the connection between directed mutation, genomic organization, and evolutionary hierarchies.

    Main Methods:

    • Analysis of genetically controlled mutator systems in organisms from bacteria to mammals.

    Related Experiment Videos

  • Examination of developmental control of genome-wide ultramutability or hypermutability.
  • Theoretical consideration of forces, configurations, and universal dimensionless constants in directed mutation.

    • Main Results:

    • Directed mutation acts as a generative process attuned to both local and universal environmental forces.
    • The response of mutagenic processes depends on genomic and transgenomic organizational levels, reflecting evolutionary hierarchies.
    • A universal dimensionless constant may mark this feature of a universal generative ordering process.

    Conclusions:

    • Directed mutation, a feature of a universal generative process, confers adaptation through dynamic completion.
    • An underlying, unitary dynamic connects ultramutability systems across all organisms.
    • This concept offers a unifying principle for biological and physical phenomena, complementing molecular approaches.