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Related Experiment Videos

Physiological deadspace during normocapnic ventilation under anaesthesia.

G D Puri1, H Singh, S Kaushik

  • 1Department of Anaesthesiology, PGIMER, Chandigarh, India.

Anaesthesia and Intensive Care
|April 23, 1999
PubMed
Summary

Male patients exhibit greater respiratory physiological deadspace (VDphys) during anesthesia compared to females, despite having lower body mass index (BMI). This finding is crucial for optimizing ventilation strategies in surgical patients.

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Authors' response.

The Indian journal of medical research·2022

Area of Science:

  • Anesthesiology
  • Respiratory Physiology
  • Critical Care Medicine

Background:

  • Understanding respiratory physiological deadspace (VDphys) is vital for effective mechanical ventilation during anesthesia.
  • Normocapnic ventilation aims to maintain normal blood carbon dioxide levels, but VDphys can vary significantly between individuals.

Purpose of the Study:

  • To investigate and compare respiratory physiological deadspace (VDphys) and deadspace to tidal volume ratio (VD/VT) between male and female patients undergoing elective non-thoracic surgery under anesthesia.
  • To identify factors influencing VDphys, including body mass index (BMI), weight, height, and body surface area (BSA).

Main Methods:

  • Studied 253 patients undergoing elective non-thoracic surgery with normocapnic ventilation using a SERVO 900B ventilator.

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  • Measured end-tidal carbon dioxide fraction (FECO2) and confirmed normocapnia with arterial blood gas analysis.
  • Calculated VDphys using Enghoff's modification of the Bohr equation.

    • Main Results:

    • Male patients had significantly higher VDphys (142.6 ml) and VDphys/mass (2.5 ml/kg) compared to females (119.4 ml and 2.2 ml/kg, respectively).
    • Males had a significantly lower body mass index (BMI) than females (20.67 vs. 22.47).
    • VDphys correlated positively with weight, height, and BSA, while VDphys/kg showed a negative correlation with BMI. A predictive equation for VDphys was developed.

    Conclusions:

    • Sex-based differences in respiratory physiological deadspace (VDphys) exist during normocapnic ventilation in surgical patients.
    • Factors such as body size and composition significantly influence VDphys, necessitating personalized ventilation strategies.
    • The derived regression equation can aid in estimating VDphys based on BSA and sex.