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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
Incidence and aetiology of heart failure; a population-based study
M R Cowie1, D A Wood, A J Coats
1Cardiac Medicine, Imperial College School of Medicine at the National Heart & Lung Institute, London, UK.
European Heart Journal
|April 23, 1999
Summary
Heart failure incidence is higher in elderly men, with coronary heart disease as the leading cause. A third of cases remain unexplained by non-invasive tests.
Area of Science:
- Cardiology
- Epidemiology
- Public Health
Background:
- Heart failure (HF) is a significant public health concern, particularly in aging populations.
- Understanding the incidence and causes of HF is crucial for effective prevention and treatment strategies.
Purpose of the Study:
- To determine the incidence and aetiology of new-onset heart failure in the general population.
- To identify demographic and etiological factors associated with heart failure.
Main Methods:
- Population-based study involving surveillance of hospital admissions and a rapid access clinic.
- Case ascertainment based on clinical assessment, ECG, chest X-ray, and echocardiography.
- Inclusion of 151,000 individuals over a 20-month period.
Main Results:
- Crude incidence rate of 1.3 cases per 1000 population per year (aged 25+).
- Incidence increases significantly with age, peaking in those 85+.
- Higher incidence observed in males (age-adjusted ratio 1.75).
- Coronary heart disease (36%) was the most common aetiology, followed by unknown (34%) and hypertension (14%).
Conclusions:
- New heart failure cases predominantly affect the elderly, with a higher incidence in men.
- Coronary heart disease is the primary identified cause, but a significant proportion (34%) have undetermined aetiology.
- Elderly individuals should be included in future heart failure clinical trials.
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