Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development of the chick olfactory nerve.

P T Drapkin1, A J Silverman

  • 1Columbia University, College of Physicians and Surgeons, Department of Anatomy and Cell Biology, New York, New York 10032, USA.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|April 23, 1999
PubMed
Summary

The olfactory nerve guides gonadotropin-releasing hormone (GnRH) neurons to the brain. Researchers studied early olfactory nerve development in embryonic chicks to understand GnRH neuron migration.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Indoor Radon Concentrations and Hematologic Traits in the Women's Health Initiative.

Epidemiology (Cambridge, Mass.)·2026
Same author

Sexual behavior triggers the appearance of non-neuronal cells containing gonadotropin-releasing hormone-like immunoreactivity.

Journal of neuroendocrinology·2011
Same author

Ultrastructural characteristics of estrogen receptor-containing neurons of the ventrolateral nucleus of the Guinea-pig hypothalamus.

Journal of neuroendocrinology·2009
Same author

Central nervous system neurons acquire mast cell products via transgranulation.

The European journal of neuroscience·2005
Same author

Early expression of chicken gonadotropin-releasing hormone-1 in the developing chick.

Journal of neuroendocrinology·2003
Same author

Distribution of gonadotropin-releasing hormone neurones in the chick forebrain is independent of lineage relationships among cells of the early nasal placode.

Journal of neuroendocrinology·2002

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Endocrinology

Background:

  • Gonadotropin-releasing hormone (GnRH) neurons are crucial for the brain-pituitary-gonadal axis.
  • These neurons originate in the olfactory placode and migrate to the brain via the olfactory nerve.
  • Proper migration of GnRH neurons is essential for reproductive functions.

Purpose of the Study:

  • To investigate the early developmental stages of the olfactory nerve in embryonic chicks.
  • To understand the temporal relationship between olfactory nerve development and GnRH neuron migration.
  • To identify potential factors influencing GnRH neuron migration into the central nervous system (CNS).

Main Methods:

  • Immunocytochemistry was used to detect neuronal and glial markers.

Related Experiment Videos

  • DiI labeling traced axonal projections from the olfactory epithelium.
  • Serial 1-micrometer plastic-embedded sections allowed detailed morphological analysis of embryonic chick olfactory nerve development (stages 17-21).

    • Main Results:

    • The olfactory nerve begins neurite outgrowth by embryonic stage 18, with sequential acquisition of neuronal markers.
    • Glial components of the nerve appear by stage 21.
    • GnRH neurons migrate towards the CNS along the olfactory nerve, reaching the brain border by stage 21, but pause before entering the CNS.

    Conclusions:

    • The olfactory nerve develops sequentially, enabling GnRH neuron migration.
    • GnRH neurons reach the CNS border via the olfactory nerve but experience a delay in entering the brain.
    • Further research is needed to elucidate the impediment to GnRH neuron entry into the brain.