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[Acute biliary pancreatitis]
1Dipartimento di Chirurgia, Università degli Studi di Roma Tor Vergata.
Abstract:
Biliary pancreatitis is a major complication of gallstones (6-8%) and mainly affects patients with microlithiasis (22%) and cholesterolosis (29%) of the gallbladder. Transient or prolonged obstruction of the ampulla represents the accepted cause and severe forms of acute pancreatitis are more frequently associated with microlithiasis (21.3% vs. 9.6%) with higher incidence of mortality (6.5% vs. 3.2%) as compared with patients with cholelithiasis. The treatment of cholelithiasis and choledocholithiasis performed electively during the same admission, after manifestations of acute pancreatitis had subsided, is an effective procedure to prevent the development of recurrent attacks of pancreatitis. Removal of the gallbladder alone in most patients may represent the definitive treatment, most common bile duct stones passing spontaneously through the papilla during the first four days after admission. Laparoscopic cholecystectomy has gained wide acceptance in the treatment of cholelithiasis, but the management of associated choledocholithiasis results still undefined. Personal strategy is to adopt a more selective approach during the acute attack, limiting the performance of ERCP-ES within the first 48 hours to those patients presenting with laboratory and clinical evidence of ampullary obstruction. If choledocholithiasis is found during laparoscopic cholecystectomy, personal recommendation is to attempt the transcystic removal of stones; if this is not feasible, a conversion of the laparoscopic procedure to an open common bile dut exploration should be carried out. Postoperative ERCP-ES does not seem a reasonably strategy, while preoperative ERCP-ES with gallbladder left in situ as treatment alone of associated biliary tract lesions may be considered in high risk patients. The surgical treatment of pancreatic lesions should be reserved to those patients with extended and unmarked or infected pancreatic necrosis, and pancreatic abscess. Closed management (surgical debridement associated with continuous local lavage of the lesser sac) is recommended, while less frequently ventral open packing should be required.
Insights
Biliary pancreatitis, a complication of gallstones, often affects patients with gallbladder microlithiasis or cholesterolosis. Prompt treatment of gallstones and bile duct stones prevents recurrent pancreatitis attacks.
Area of Science:
- Gastroenterology
- Hepatobiliary Surgery
- Endoscopic Retrograde Cholangiopancreatography
Context:
- Biliary pancreatitis is a significant complication of gallstones, particularly impacting patients with gallbladder microlithiasis and cholesterolosis.
- Ampullary obstruction is the primary cause, with severe pancreatitis and mortality more common in microlithiasis cases compared to cholelithiasis.
- Gallstone management during the same admission post-pancreatitis prevents recurrence, with gallbladder removal often being definitive.
Purpose:
- To outline an effective management strategy for biliary pancreatitis and associated choledocholithiasis.
- To define the role of endoscopic retrograde cholangiopancreatography with sphincterotomy (ERCP-ES) and surgical interventions.
- To guide treatment decisions based on clinical evidence and patient risk stratification.
Summary:
- A selective approach to ERCP-ES within 48 hours is recommended for patients with clear signs of ampullary obstruction.
- Laparoscopic cholecystectomy for cholelithiasis may involve transcystic stone removal or conversion to open exploration for choledocholithiasis.
- Surgical management of pancreatic necrosis or abscesses should be reserved for severe, complicated cases, with closed management preferred.
Impact:
- Optimizing the timing and approach for ERCP-ES and surgical interventions can improve outcomes for biliary pancreatitis.
- This strategy aims to reduce recurrent pancreatitis, mortality, and complications associated with gallstone disease.
- Refined management protocols can lead to more effective and less invasive treatments for complex hepatobiliary and pancreatic conditions.