[Morphologic changes in the testes of white rats chronically subjected to vofatox 50]

The chronic action of the preparation vofatox 50 causes changes in the spermatopoeitic epithelium of white rats, which depend on the doses and duration of intoxication. There is an increased vascular permeability and degenerative changes in the spermatogenic epithelium, a reduction of the mitotic process and also index of spermatogenesis at the initial stages. The later changes are manifested by more formed changes in the spermatopoietic cells, appearance of gigantic multicellular forms, lack of sprematozoa in a large number of canaliclues and fibrosis of blood vessels. The changes in the testis are the result of the general toxic action of the preparation.