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A complete remote-control system for reliable preparation of [18F]altanserin
P Z Tan1, R M Baldwin, R Soufer
1VA PET Center, Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA. pingzhong.tan@yale.edu
Abstract:
A complete remote control system was constructed for production of the PET 5-HT2A ligand [18F]altanserin by nitro-for-fluoro exchange. Comparing with published methods, the key features include (1) conducting azeotropic distillation and nucleophilic displacement in an open vessel heated by a commercial microwave oven; (2) purifying the product by a single HPLC procedure and (3) removing HPLC solvent by solid phase extraction. The preparation took 114 min with 23% yield and high quality.