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Related Experiment Videos

Lamotrigine-induced tourettism.

C T Lombroso1

  • 1Department of Neurology, Children's Hospital, and Harvard Medical School, Boston, MA, USA.

Neurology
|April 24, 1999
PubMed
Summary
This summary is machine-generated.

Lamotrigine (LTG) can rarely cause dose-related Tourette syndrome (TS) symptoms in children. This suggests LTG may impact striatal dopamine uptake by affecting excitatory amino acids, contributing to TS pathogenesis.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Neurology

Background:

  • Lamotrigine (LTG) is an antiepileptic drug with broad efficacy.
  • LTG is generally well-tolerated, with idiosyncratic rashes being a known side effect.

Observation:

  • Three pediatric cases are presented where lamotrigine induced dose-related Tourette syndrome (TS) symptoms.
  • This rare phenomenon provides insight into the multifactorial causes of TS.

Findings:

  • LTG's primary antiseizure mechanism involves blocking excessive presynaptic release of excitatory amino acids (EAAs) during sustained neuronal firing.
  • LTG does not inhibit spontaneous EAA release, preserving normal neuronal functions.

Implications:

  • The dopamine hypothesis suggests striatal dopamine uptake dysfunction in TS pathogenesis.

Related Experiment Videos

  • EAAs can disrupt striatal dopamine uptake; LTG may induce TS symptoms at high doses by inadequately regulating EAA release in the striatum.