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Related Experiment Videos

Risk factors for placenta accreta.

T H Hung1, W Y Shau, C C Hsieh

  • 1Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taipei, Taiwan.

Obstetrics and Gynecology
|April 24, 1999
PubMed
Summary
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Placenta previa, elevated second-trimester AFP and free beta-hCG levels, and advanced maternal age are key risk factors for placenta accreta. This study identified these predictors in a large Asian cohort.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Reproductive Health

Background:

  • Placenta accreta is a significant obstetric complication associated with increased maternal morbidity and mortality.
  • Identifying risk factors is crucial for early detection and management of placenta accreta.
  • Previous studies have suggested several potential risk factors, but large-scale cohort data are needed.

Purpose of the Study:

  • To identify independent risk factors for placenta accreta.
  • To analyze data from a large Asian cohort for risk factor identification.
  • To provide evidence for improved screening and diagnosis of placenta accreta.

Main Methods:

  • A retrospective cohort study was conducted using data from the Taiwan Down Syndrome Screening Group.

Related Experiment Videos

  • Included were 9,349 pregnancies screened for Down syndrome between 14-22 weeks' gestation.
  • Multiple logistic regression analysis was performed to identify independent risk factors for placenta accreta.

    • Main Results:

    • Placenta previa was strongly associated with placenta accreta (OR 54.2).
    • Elevated second-trimester serum levels of alpha-fetoprotein (AFP) (OR 8.3) and free beta-hCG (OR 3.9) were significant risk factors.
    • Advanced maternal age (≥35 years) also increased the risk (OR 3.2).

    Conclusions:

    • Placenta previa is the most significant risk factor for placenta accreta.
    • Abnormally elevated second-trimester AFP and free beta-hCG levels are associated with increased risk.
    • Advanced maternal age is an independent risk factor for placenta accreta.