Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Object-oriented biomedical system modeling--the rationale.

M Hakman1, T Groth

  • 1Department of Medical Sciences, Uppsala University, Sweden. mikael.hakman@ibm.net

Computer Methods and Programs in Biomedicine
|April 24, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence for Extending Anomalous Miocene Volcanism at the Edge of the East Antarctic Craton.

Geophysical research letters·2020
Same author

Engineering osteogenic microenvironments by combination of multilayers from collagen type I and chondroitin sulfate with novel cationic liposomes.

Materials today. Bio·2020
Same author

A comparison of clinical outcomes of acute testicular torsion between prepubertal and postpubertal males.

Journal of pediatric urology·2019
Same author

Commentary to 'Impact of pelvic immobilization techniques on the outcomes of primary and secondary closures of classic bladder exstrophy'.

Journal of pediatric urology·2019
Same author

Short-term outcomes of the multi-institutional bladder exstrophy consortium: Successes and complications in the first two years of collaboration.

Journal of pediatric urology·2017
Same author

Modulation of osteogenic activity of BMP-2 by cellulose and chitosan derivatives.

Acta biomaterialia·2011
Same journal

Accounting for approximation errors using surrogate-based parameter estimation of cardiac mechanics digital twins.

Computer methods and programs in biomedicine·2026
Same journal

Facial iPPG heatmap patterns based on period-aware autoencoder show association with carotid atherosclerosis towards non-contact hemodynamic assessment.

Computer methods and programs in biomedicine·2026
Same journal

Explainable machine learning models predict liver fibrosis risk and outcome in the general population: Development and multi-cohort external validation.

Computer methods and programs in biomedicine·2026
Same journal

Evaluation of surrogate endpoints for survival outcomes using the surrogate package in R.

Computer methods and programs in biomedicine·2026
Same journal

Relative spectral and frication-based descriptors as numerical indicators of place of articulation shifts in fricatives produced by Polish children.

Computer methods and programs in biomedicine·2026
Same journal

Leaflet resection improves valve expansion and hemodynamic performance in redo TAVI with balloon- and self-expanding transcatheter heart valve configurations.

Computer methods and programs in biomedicine·2026
See all related articles

Object-Oriented Biomedical (Continuous) System Modelling (OOBSM) offers a clearer, less error-prone approach to complex bio-medical models. This method enhances knowledge communication and model integration across research groups.

Area of Science:

  • Biomedical Engineering
  • Computational Biology
  • Systems Biology

Background:

  • Existing continuous system modeling languages present limitations for complex, interdisciplinary, and hierarchical bio-medical models.
  • Current techniques hinder easy exchange and communication of model knowledge between research groups.
  • There is a need for improved modeling methodologies in pathophysiology and bio-medical research.

Purpose of the Study:

  • To provide a rationale and tutorial for Object-Oriented Biomedical (Continuous) System Modelling (OOBSM).
  • To define requirements for simplifying complex bio-medical and pathophysiological model development.
  • To establish criteria for communicable model knowledge and component-based model integration.

Main Methods:

  • Development and presentation of the Object-Oriented Biomedical (Continuous) System Modelling (OOBSM) framework.

Related Experiment Videos

  • Comparative analysis of OOBSM against existing continuous system modeling techniques.
  • Specification of requirements for inter-group knowledge sharing and model composability.

    • Main Results:

    • OOBSM facilitates easier, less error-prone, and conceptually clearer work with complex bio-medical models.
    • Existing modeling languages are unsuitable for complex, interdisciplinary, multilevel, hierarchical models and components.
    • Current languages impede effective knowledge exchange between research sites.

    Conclusions:

    • Object-oriented and distributed object methodologies are feasible and suitable for advanced biomedical system modeling.
    • OOBSM enhances the communicability and reusability of bio-medical models.
    • The proposed OOBSM approach addresses limitations of traditional continuous system modeling.