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Rapid recovery of bone mass in hypercalciuric, osteoporotic men treated with hydrochlorothiazide
J S Adams1, C F Song, V Kantorovich
1Burns and Allen Research Institute and Cedars-Sinai Medical Center, University of California, Los Angeles, School of Medicine 90048, USA. adamsj@cshs.org
Background:
Chronic hypercalciuria can contribute to osteoporosis, particularly in men.
Objective:
To ascertain the effects of resolution of hypercalciuria on bone mineral density.
Design:
Case series.
Setting:
Referral service for metabolic bone disease in a tertiary-care teaching hospital.
Patients:
Five male patients (42 to 66 years of age) with hypercalciuria and osteoporosis.
Intervention:
Hydrochlorothiazide, 25 mg twice daily, for a mean (+/- SD) of 7.8 +/- 3.6 months.
Measurements:
Fasting urinary calcium:creatinine ratio, serum calciotropic hormone levels, and bone mineral density before and after hydrochlorothiazide administration.
Results:
Hydrochlorothiazide resolved hypercalciuria and increased bone mineral density at a rate of 8% and 3% per year at the spine and hip, respectively.
Conclusions:
Hydrochlorothiazide treatment in hypercalciuric and osteoporotic men was associated with a rapid rebound increase in bone mineral density.