Related Experiment Videos
Review article: anthranoid laxatives and their potential carcinogenic effects
B A van Gorkom1, E G de Vries, A Karrenbeld
1Department of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands.
Alimentary Pharmacology & Therapeutics
|April 24, 1999
Summary
Anthranoid laxatives, natural remedies, damage colon cells, leading to pseudomelanosis coli. Long-term use is not recommended due to potential cancer risks.
Area of Science:
- Gastroenterology
- Pharmacology
- Oncology
Background:
- Anthranoid laxatives are natural compounds utilized for their laxative properties.
- Their chemical structure facilitates unabsorbed transport to the colon for metabolic activation.
- Active metabolites damage colonic epithelial cells, altering absorption, secretion, and motility.
Purpose of the Study:
- To investigate the effects of anthranoid laxatives on colonic mucosa.
- To explore the association between anthranoid laxative use and colorectal carcinoma risk.
- To evaluate the potential role of anthranoid laxatives in tumorigenesis.
Main Methods:
- Analysis of colonic epithelial cell damage and apoptotic bodies.
- Histopathological examination of colonic mucosa for pseudomelanosis coli.
- Review of in vitro, animal, and human studies on laxative effects and cancer risk.
Main Results:
- Anthranoid laxatives cause epithelial cell damage, leading to pseudomelanosis coli.
- Pseudomelanosis coli, linked to chronic laxative abuse, is associated with increased colorectal cancer risk.
- In vitro and animal studies suggest anthranoid laxatives may initiate and promote tumors; human studies indicate tumor-promoting activities.
Conclusions:
- Short-term use of anthranoid laxatives is generally safe.
- Chronic use of anthranoid laxatives is not recommended due to potential adverse effects and cancer risk.
- Further research is warranted to fully elucidate the long-term implications of anthranoid laxative consumption.