Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modelling uveal melanoma.

A J Foss1, I A Cree, P J Dolin

  • 1Directorate of Ophthalmology, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH.

The British Journal of Ophthalmology
|April 27, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

WHO 2022 classification of penile and scrotal cancers: updates and evolution.

Histopathology·2022
Same author

Choroidal metastasis from follicular cell thyroid carcinoma masquerading as circumscribed choroidal haemangioma.

Case reports in oncological medicine·2014
Same author

Targeting EGFR and PI3K pathways in ovarian cancer.

British journal of cancer·2013
Same author

Identification of markers of prostate cancer progression using candidate gene expression.

British journal of cancer·2011
Same author

Circulating tumour markers can define patients with normal colons, benign polyps, and cancers.

British journal of cancer·2011
Same author

Predicting local control of choroidal melanomas following ¹⁰⁶Ru plaque brachytherapy.

The British journal of ophthalmology·2010
Same journal

Identifying patients with poor visual outcomes after primary rhegmatogenous retinal detachment surgery using machine learning.

The British journal of ophthalmology·2026
Same journal

Incidence of bilateral disease and choroidal neovascularisation in punctate inner choroiditis.

The British journal of ophthalmology·2026
Same journal

Reference map of multimodal vision deficits in intermediate age-related macular degeneration: contrast sensitivity and low-contrast visual acuity.

The British journal of ophthalmology·2026
Same journal

Commentary on 'identifying patients with poor visual outcomes after primary rhegmatogenous retinal detachment surgery using machine learning'.

The British journal of ophthalmology·2026
Same journal

Automated deep learning-based retinoschisis and detachment volume measurement in pathological myopia with posterior scleral contraction.

The British journal of ophthalmology·2026
Same journal

Bacterial keratitis: a global review of current practices, challenges and innovations.

The British journal of ophthalmology·2026
See all related articles

Uveal melanoma mortality patterns vary by age, with underreporting in England and Wales over age 65. A four-step oncogenesis model is proposed for ocular melanoma under age 65.

Area of Science:

  • Ophthalmology
  • Oncology
  • Biostatistics

Background:

  • Uveal melanoma mortality patterns by age remain inconsistent.
  • Understanding these patterns aids in modeling disease complexity.
  • Ocular cancer trends serve as an indirect measure for uveal melanoma mortality.

Purpose of the Study:

  • Examine age-specific mortality rates for ocular cancer.
  • Compare uveal melanoma mortality trends across England/Wales, USA, and Canada.
  • Relate findings to models predicting metastatic disease progression.

Main Methods:

  • Age-specific mortality data analyzed for England/Wales, USA, and Canada.
  • Log-log models fitted to mortality data to assess age-related trends.
  • Slopes of log-log plots used to quantify disease complexity.

Related Experiment Videos

Main Results:

  • Log-log models fit US and Canadian data well.
  • England/Wales data deviated for individuals over 65, suggesting underreporting.
  • Mortality models indicate four rate-limiting steps in oncogenesis; incidence models suggest three to four.

Conclusions:

  • Significant underreporting/underdiagnosis of ocular melanoma in England/Wales for those over 65.
  • A four-step model for uveal melanoma oncogenesis is proposed for those under 65.
  • Primary tumor development involves growth and angiogenesis; metastasis involves a single rate-limiting step.