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Related Experiment Videos

Signalling sphingomyelinases: which, where, how and why?

T Levade1, J P Jaffrézou

  • 1INSERM Unit 466, Laboratoire de Biochimie, Maladies Métaboliques, Institut Louis Bugnard, Bât. L3, C.H.U. Rangueil, 1 Avenue Jean Poulhès, E 9910, Toulouse Cedex 4, France. levade@rangueil.inserm.fr

Biochimica Et Biophysica Acta
|April 27, 1999
PubMed
Summary
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This review covers sphingomyelinase (SMase) activation in mammalian cell signaling. It details SMase regulation, identity controversies, and its role in ceramide production, highlighting key cellular factors influencing its activity.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Signaling

Background:

  • Sphingomyelinase (SMase) activation is crucial for mammalian lipid signaling pathways.
  • SMase hydrolyzes sphingomyelin to ceramide upon cellular stimulation.
  • Understanding SMase function is key to elucidating complex cellular processes.

Purpose of the Study:

  • To review current knowledge on the nature and regulation of signaling SMases.
  • To discuss the roles of various SMases in cell signaling, addressing identity controversies.
  • To highlight the subcellular localization and regulatory factors of signaling SMases.

Main Methods:

  • Literature review and synthesis of existing research on sphingomyelinase.
  • Analysis of studies investigating SMase identity and function.

Related Experiment Videos

  • Examination of cellular factors affecting SMase activity.

    • Main Results:

    • Summarizes the current understanding of signaling SMase(s) and their regulation.
    • Discusses the controversial identity of the phospholipase(s) involved in signaling.
    • Identifies key regulatory agents including lipids, kinases, proteases, and glutathione.

    Conclusions:

    • Signaling SMases play a vital role in mammalian cell communication.
    • Further research is needed to fully resolve the identity and specific roles of different SMases.
    • Cellular factors provide intricate control over SMase activity, impacting downstream signaling events.