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Updated: Aug 16, 2026

Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake
Published on: September 21, 2017
[Low serum dopamine -- beta-hydroxylase activity in patients with panic disorder]
J Landowski1, W Lysiak-Szydłowska
1Katedry i I Kliniki Chorób Psychicznych AM w Gdańsku.
Abstract:
Serum dopamine-beta-hydroxylase (DBH) activity was determined in the following diagnostic groups of patients (DSM-III-R criteria): panic disorder (n = 16), generalized anxiety disorder (n = 10), hypochondrical disorder (n = 16). Twenty healthy persons constituted the control group. Enzyme activity in the group of panic disorder (9.3 +/- 12.5 IU/l) was statistically significantly lower as compared to the groups: control (20.1 +/- 8.1 IU/l), generalized anxiety disorder (17.6 +/- 13.5 IU/l) and hypochondrical disorder (13.6 +/- 10.6 IU/l). Possible relationship between low serum DBH activity and panic disorder is not clear.
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