Related Experiment Videos
Effect of maternal low dose aspirin on neonatal platelet function
R Dasari1, A Narang, K Vasishta
1Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh.
Indian Pediatrics
|April 27, 1999
Summary
Maternal low-dose aspirin use during pregnancy is safe for newborns. Studies show no adverse effects on infant platelet function or increased bleeding risk, ensuring infant safety.
Area of Science:
- Neonatal Medicine
- Pharmacology
- Hematology
Background:
- Low-dose aspirin is frequently prescribed during pregnancy for various indications.
- Potential effects of maternal aspirin on neonatal platelet function require thorough evaluation.
Purpose of the Study:
- To assess the impact of maternal low-dose aspirin ingestion on the platelet function of newborns.
Main Methods:
- A prospective, randomized, placebo-controlled study was conducted.
- Umbilical cord blood from 25 neonates exposed to maternal aspirin and 25 controls was analyzed for platelet count, coagulation profile, and platelet aggregation.
- Platelet function was assessed using various agonists.
Main Results:
- No significant differences were observed in platelet counts between the aspirin-exposed and control groups.
- Coagulation parameters, including prothrombin time index and PTTK, showed no significant variations.
- Platelet aggregation studies revealed no significant differences in platelet function, and no neonates exhibited bleeding complications.
Conclusions:
- Maternal low-dose aspirin use during pregnancy is safe for newborns.
- There are no adverse effects on neonatal platelet function or hemostasis.
- Findings support the continued use of low-dose aspirin in pregnancy when indicated.