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Translation initiation factor 4E
L McKendrick1, V M Pain, S J Morley
1Biochemistry Laboratory, School of Biological Sciences, University of Sussex, Falmer, Brighton, UK. bdfa4@sussex.ac.uk
The International Journal of Biochemistry & Cell Biology
|April 27, 1999
Abstract:
Translation initiation factor 4E (eIF4E) binds the 7-methylguanosine cap structure of mRNA and mediates recruitment of mRNA to ribosomes, with the potential of regulating the overall rate of translation and discriminating between different RNAs. Increased translation is required for progress through the cell cycle, and it is therefore not surprising that eIF4E has oncogenic properties when overexpressed. The function of this review is to summarise what is known about eIF4E gene and protein structure, biological function and medical relevance.