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Alginate-pectin-poly-L-lysine particulate as a potential controlled release formulation.

P Liu1, T R Krishnan

  • 1School of Pharmacy, Memorial University of Newfoundland, St John's, Canada.

The Journal of Pharmacy and Pharmacology
|April 27, 1999
PubMed
Summary
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New alginate-polylysine-pectin particulates enhance oral drug absorption. These novel drug delivery systems show improved resistance and modulated release, offering potential for poorly absorbed medications.

Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biotechnology

Background:

  • Developing effective drug delivery systems is crucial for improving therapeutic outcomes, especially for orally administered drugs with poor absorption.
  • Particulate drug delivery systems offer potential for controlled release and enhanced bioavailability.
  • Alginate and pectin are biocompatible polymers with potential for drug encapsulation and absorption enhancement.

Purpose of the Study:

  • To develop and characterize novel drug delivery particulates using alginate, polylysine, and pectin.
  • To evaluate the in vitro release profiles of model drugs (theophylline, chlorothiazide, indomethacin) from these particulates.
  • To assess the impact of these particulates on paracellular drug absorption using mannitol and Caco-2 cell monolayers.

Main Methods:

Related Experiment Videos

  • Preparation of drug delivery particulates using alginate, polylysine, and pectin.
  • In vitro drug release studies under different pH conditions.
  • Assessment of paracellular drug absorption across Caco-2 cell monolayers using mannitol as a model compound.

Main Results:

  • Alginate-polylysine-pectin particulates demonstrated enhanced robustness, particularly in acidic conditions, due to pectin incorporation.
  • Pectin modulated drug release profiles in alkaline pH.
  • These particulates significantly enhanced paracellular absorption of mannitol across Caco-2 cells by approximately threefold.
  • Drug release kinetics followed first-order or square-root time models depending on drug loading.

Conclusions:

  • Alginate-polylysine-pectin particulates offer a promising drug delivery platform combining bioadhesion, absorption enhancement, and sustained release properties.
  • The system shows potential for improving the oral delivery of drugs with poor absorption.
  • The use of pectin contributes to particulate stability and controlled drug release.