Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to subjects...
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Progression patterns and clinical outcomes in patients with cutaneous squamous-cell carcinoma following anti-PD-1 therapy failure.

ESMO open·2026
Same author

Evaluating the ability of AI chatbots to provide informed consent information for common oncological surgeries.

Annals of the Royal College of Surgeons of England·2025
Same author

Impact of Dyslipidemia, Cardiovascular Disease, Smoking, and Stroke Type by Brain Imaging on Pneumonia Risk in ICU Stroke Patients: A Cross-Sectional Observational Study.

La Clinica terapeutica·2025
Same author

Demographic factors associated with oral health behaviour in children aged 5-17 years in Algeria.

Community dental health·2024
Same author

Antimicrobial effects of XF drugs against <i>Candida albicans</i> and its biofilms.

Frontiers in fungal biology·2023
Same author

Cochlear implant eligibility in an adult hearing aid population: a multi-perspective service evaluation of a patient referral pathway at a British district general hospital.

The Journal of laryngology and otology·2022

Related Experiment Video

Updated: Jul 9, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Measuring costs in multisite randomized controlled trials: lessons from the VA Cooperative Studies Program.

D Hynes1, D Reda, A Giobbie-Hurder

  • 1Department of Veterans Affairs Cooperative Studies Program Coordinating Center, Edward Hines Jr. VA Hospital, Hines, IL 60141-5000, USA. hynes@research.hines.med.va.gov

Medical Care
|April 27, 1999
PubMed
Summary

Measuring health care costs in clinical trials requires robust methods. This study details experiences from the VA Cooperative Studies Program in collecting utilization and economic data for health interventions.

More Related Videos

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living
08:36

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living

Published on: July 28, 2022

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
08:33

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

Related Experiment Videos

Last Updated: Jul 9, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living
08:36

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living

Published on: July 28, 2022

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
08:33

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

Area of Science:

  • Health Economics
  • Clinical Trial Analysis
  • Health Services Research

Background:

  • Growing interest in the economic impact of novel healthcare interventions.
  • Variability in economic impact assessments due to differing assumptions and methodologies.
  • Need for standardized approaches to measure healthcare costs in clinical studies.

Purpose of the Study:

  • To describe experiences and strategies for measuring healthcare utilization and costs within the VA Cooperative Studies Program.
  • To illustrate methods for economic data collection in multisite randomized clinical trials (RCTs).
  • To inform health planning and policy by providing evidence on the cost of healthcare innovations.

Main Methods:

  • Direct measurement of healthcare utilization within two multisite RCTs.
  • Collection of economic data concurrently with clinical intervention evaluation.
  • Application of accepted health economic approaches in data collection and analysis.

Main Results:

  • Direct measurement of healthcare utilization provides valuable cost data for clinical interventions.
  • Experiences highlight the feasibility of integrating economic assessments into RCTs.
  • Substantial resources are necessary for comprehensive cost-of-care evidence generation.

Conclusions:

  • Future VA multisite studies should incorporate standardized health economic methodologies.
  • Accurate cost data collection is crucial for effective health planning and policy development.
  • Evidence on the cost of healthcare innovations is vital for both internal and external healthcare systems.