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Immunostaining for cyclin D1 and the diagnosis of mantle cell lymphoma: is there a reliable method?
J K Chan1, K D Miller, P Munson
1Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Histopathology
|April 27, 1999
Abstract:
Immunostaining for cyclin D1 has become essential for the reliable diagnosis of mantle cell lymphoma (MCL). MCL is associated with a poor prognosis and its distinction from other small B-cell lymphomas is clinically important. However, many diagnostic laboratories report problems in finding a reliable method. The following articles by Chan and by Miller, Munson & Isaacson discuss the common problems and describe successful methods with advice on diagnostic interpretation.