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Bioactive sesquiterpenes from a Taiwanese marine sponge Parahigginsia sp
1Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
Journal of Natural Products
|April 28, 1999
Abstract:
Five new sesquiterpenes, parahigginols A-D (1-4) and parahigginic acid (5), have been isolated from a Taiwanese marine sponge Parahigginsia sp. The structural assignments of the new compounds were based on their spectral data, including 1D and 2D NMR. Biological studies revealed that compounds 2-5 exhibited cytotoxicity against murine P-388 and human KB16, A549, and HT-29 tumor cells.