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Disulfide bridges are not involved in penicillin-binding protein 1b dimerization in Escherichia coli
C Chalut1, M H Remy, J M Masson
1Institut de Pharmacologie et de Biologie Structurale du CNRS, Toulouse, France.
Abstract:
PBP1b can be found as a dimer in Escherichia coli. Previous results suggested that dimerization involved the cysteine(s) in an intermolecular disulfide bond. We show that either deletion mutants or a mutant without cysteines is fully active and still binds penicillin and that the latter can also form dimers.
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