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Isolation and characterization of the Saccharomyces cerevisiae XPT1 gene encoding xanthine phosphoribosyl transferase
M L Guetsova1, T R Crother, M W Taylor
1Institut de Biochimie et Génétique Cellulaires, CNRS UPR9026, F-33077 Bordeaux Cedex, France.
Journal of Bacteriology
|April 28, 1999
Abstract:
A new Saccharomyces cerevisiae gene, XPT1, was isolated as a multicopy suppressor of a hypoxanthine phosphoribosyl transferase (HPRT) defect. Disruption of XPT1 affects xanthine utilization in vivo and results in a severe reduction of xanthine phosphoribosyl transferase (XPRT) activity while HPRT is unaffected. We conclude that XPT1 encodes XPRT in yeast.