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Epidemiologic survey on organophosphate-induced delayed polyneuropathy (OPIDP) among patients recovered from
Abstract:
As Methamidophos (MAF) is currently responsible for half of the pesticide intoxications and fatality cases in China, the need to assess the frequency and the characteristics of the OPIDP among the victims who recovered from MAF poisoning is obvious. One-hundred and four subjects suffering from MAF intoxication were selected according to their medical records in the local rural hospitals in the Mu-du suburb of Su-Zhou, and the Shi-Qiu suburb of Nanjing. Face-to-face interviews were performed during home visits to all selected subjects, with the only exception of 4 patients. In those cases, information was provided by their kin relatives. Fourteen cases of delayed polyneuropathy (OPIDP) were identified: all patients who suffered from OP poisoning and had OPIDP showed a typical clinical course. The overall incidence of OPIDP was surprisingly high: 13.5%. The risk of OPIDP was associated with the severity of the intoxication. No association was found between OPIDP incidence and sex, age or treatment with dexametholone during the acute phase of the disease (RR = 0.98, p = 0.79). All 14 cases of OPIDP recovered in one and a half year without any permanent disability.
Insights
Methamidophos (MAF) poisoning can cause Organophosphate-Induced Delayed Polyneuropathy (OPIDP) in 13.5% of survivors. Fortunately, all identified OPIDP cases recovered fully within 18 months.
Area of Science:
- Toxicology
- Neurology
- Public Health
Background:
- Methamidophos (MAF) is a significant cause of pesticide poisoning and fatalities in China.
- Assessing the incidence and characteristics of Organophosphate-Induced Delayed Polyneuropathy (OPIDP) in MAF survivors is crucial.
Purpose of the Study:
- To determine the frequency and clinical features of OPIDP in patients who recovered from Methamidophos (MAF) intoxication.
- To identify risk factors associated with OPIDP development after MAF poisoning.
Main Methods:
- A cohort of 104 subjects with MAF intoxication was identified from rural hospitals.
- Face-to-face interviews and medical record reviews were conducted to assess for OPIDP.
- Statistical analysis was performed to evaluate associations between OPIDP and patient demographics or treatments.
Main Results:
- Fourteen cases of OPIDP were identified, resulting in an overall incidence of 13.5%.
- OPIDP risk was significantly associated with the severity of MAF intoxication.
- No correlation was found between OPIDP incidence and sex, age, or dexamethasone treatment.
Conclusions:
- Organophosphate-Induced Delayed Polyneuropathy (OPIDP) occurs with a high incidence in Methamidophos (MAF) poisoning survivors.
- While OPIDP can develop, recovery is complete within 18 months without permanent disability.
- Severity of initial poisoning is a key factor in OPIDP development.