Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mast cell profile in prostatic lesions.

T Amir1, R R Pai, C V Raghuveer

  • 1Pathology Department, Kasturba Medical College, Mangalore.

Indian Journal of Medical Sciences
|April 28, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

2021 Canadian Surgery Forum: Virtual, online Sept. 21-24, 2021.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Evaluation of enzyme-linked immunosorbent assay plasma p16INK4a protein in squamous cell carcinoma in uterine cervix: A case-control study.

Journal of cancer research and therapeutics·2022
Same author

Comparison of radiation dose between 2D digital stereotactic versus digital breast tomosynthesis-guided breast biopsies.

European journal of radiology·2020
Same author

Metastatic nasopharyngeal carcinoma with extensive Langerhans' cell reaction and its significance: a case initially diagnosed by fine needle aspiration cytology.

Cytopathology : official journal of the British Society for Clinical Cytology·2016
Same author

A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult.

Journal of cancer research and therapeutics·2015
Same author

Correlation of Clinico-pathological Classification of Hansen's Disease in a South Indian City.

Indian journal of leprosy·2015
Same journal

An unusual formation of sciatic nerve.

Indian journal of medical sciences·2014
Same journal

Chronic myeloid leukemia with hyperdiploidy: a case report with review of literature.

Indian journal of medical sciences·2014
Same journal

A 24 year-old male with yellow nail syndrome having bronchiactasis without pleural effusion as a pulmonary manifestation.

Indian journal of medical sciences·2014
Same journal

Yellow oleander poisoning in eastern province: an analysis of admission and outcome.

Indian journal of medical sciences·2014
Same journal

Prevalence and determining factors of anemia and malnutrition among Egyptian children.

Indian journal of medical sciences·2014
Same journal

Autonomic system modification in Zen practitioners.

Indian journal of medical sciences·2014
See all related articles

Mast cells, crucial immune cells, show varied distribution in prostate tissues. Their counts differ significantly between benign conditions like nodular hyperplasia and prostate cancer, suggesting diagnostic potential.

Area of Science:

  • Urology
  • Pathology
  • Immunology

Background:

  • Mast cells play roles in inflammation and tissue remodeling.
  • Their specific distribution in various prostate pathologies is not well-characterized.

Purpose of the Study:

  • To analyze mast cell distribution in common prostate lesions.
  • To investigate the potential of mast cell counts in differentiating benign from malignant prostatic conditions.

Main Methods:

  • Analysis of 173 consecutive prostatic biopsy specimens.
  • Categorization into nodular hyperplasia (with/without prostatitis), prostatic intraepithelial neoplasia, and adenocarcinoma.
  • Toluidine blue staining to quantify mast cells per square millimeter.

Main Results:

Related Experiment Videos

  • Significantly higher mast cell counts in fibromuscular stroma versus glandular areas in nodular hyperplasia.
  • Very significantly lower mast cell counts in inflammatory lesions, likely due to degranulation.
  • Absence or low mast cell counts observed in adenocarcinoma, with some concentration around tumors.

Conclusions:

  • Mast cell distribution varies considerably across different prostatic lesions.
  • Low mast cell counts in adenocarcinoma warrant further investigation for diagnostic utility.
  • Further studies are needed to evaluate mast cell counts for differentiating malignant from benign and atypical prostate conditions.