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Mannitol and cardiac surgery.

M Poullis1

  • 1Department of Cardiothoracic Surgery, Hammersmith Hospital, London, England, UK. mpoullis@rpms.ac.uk

The Thoracic and Cardiovascular Surgeon
|April 28, 1999
PubMed
Summary
This summary is machine-generated.

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Mannitol is a versatile medication with benefits for the kidneys and brain, widely used in medicine and cardiac surgery. While effective, its use requires consideration of potential side effects, as reviewed in medical literature.

Area of Science:

  • Pharmacology
  • Nephrology
  • Cardiology

Background:

  • Mannitol is a widely utilized osmotic diuretic in medical practice.
  • Its applications span various medical fields, including cardiac surgery.
  • Key actions involve the kidneys and brain, with additional effects on other organs and physiological processes.

Purpose of the Study:

  • To review the medical literature on mannitol use over the past 30 years.
  • To highlight the diverse applications and physiological effects of mannitol.
  • To discuss the known side effects associated with mannitol administration.

Main Methods:

  • Comprehensive review of medical literature.
  • Analysis of studies published over the last three decades.
  • Synthesis of information regarding mannitol's efficacy and safety.

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Main Results:

  • Mannitol demonstrates significant benefits for kidney and brain function.
  • Its use is prevalent in cardiac surgery and various other medical contexts.
  • The review encompasses mannitol's effects on organs, red blood cells, free radicals, and nitric oxide.

Conclusions:

  • Mannitol remains a valuable therapeutic agent with broad medical applications.
  • Understanding its multifaceted actions and potential side effects is crucial for safe and effective clinical use.
  • Continued review of medical literature supports informed mannitol administration.