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Related Experiment Videos

Laser Doppler flowmetry and optic nerve head blood flow.

B L Petrig1, C E Riva, S S Hayreh

  • 1Institut de Recherche en Ophtalmologie, Sion, Switzerland.

American Journal of Ophthalmology
|April 28, 1999
PubMed
Summary

Laser Doppler flowmetry primarily measures superficial optic nerve head blood flow, not deeper layers crucial for diagnosing conditions like glaucoma. New techniques may offer improved deep-layer circulation assessment.

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Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Medical Imaging

Background:

  • Optic nerve head (ONH) ischemic disorders cause significant visual impairment.
  • ONH circulation involves superficial layers (central retinal artery) and deep layers (posterior ciliary arteries).

Purpose of the Study:

  • To determine which ONH circulation components are measured by laser Doppler flowmetry (LDF).
  • To assess LDF sensitivity to blood flow changes in different ONH layers.

Main Methods:

  • Rhesus monkey eyes underwent LDF measurements.
  • Experimental occlusions of central retinal artery (CRA), posterior ciliary arteries (PCAs), and combined occlusions were performed.
  • Fluorescein fundus angiography assessed ONH, choroidal, and retinal circulations.

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Main Results:

  • CRA occlusion significantly decreased LDF flow by 39%.
  • Combined CRA and PCA occlusion caused a nonsignificant 57% flow reduction.
  • PCA occlusion alone resulted in a nonsignificant 17% increase in LDF flow.

Conclusions:

  • Standard LDF is mainly sensitive to superficial ONH blood flow.
  • LDF is less sensitive to deeper ONH regions, limiting its use in conditions like glaucoma.
  • Advanced LDF modalities may enable selective measurement of deep-layer circulation.