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[Hepatitis B and ratio of masculinity]
Revue Francaise De Transfusion Et Immuno-Hematologie
|December 1, 1976
Summary
Hepatitis B virus (HBV) infection in mothers is linked to a higher male-to-female sibling ratio in affected families. This suggests a potential influence of maternal HBV on offspring sex distribution.
Area of Science:
- Hepatology
- Human Genetics
- Epidemiology
Context:
- Study focuses on families of blood donors in Languedoc identified as chronic carriers of Hepatitis B surface antigen (HBsAg).
- Examines the sibling masculinity ratio (male to female births) within these families.
Purpose:
- To investigate potential correlations between Hepatitis B virus (HBV) infection status in parents and the sex ratio of their offspring.
- To determine if maternal or paternal HBV carriage influences the masculinity ratio.
Summary:
- A significantly higher masculinity ratio (1.32) was observed in siblings of HBsAg-positive families compared to the general population (1.05).
- This ratio was notably elevated in families with maternal HBV infection (1.73) but only slightly increased with paternal infection (1.09).
Impact:
- Suggests a potential biological mechanism where maternal Hepatitis B infection may influence the sex ratio of offspring.
- Highlights the need for further research into the reproductive health implications of HBV carriage.