Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extremely acute phenytoin-induced peripheral neuropathy.

H Yoshikawa1, T Abe, Y Oda

  • 1Department of Pediatrics, Niigata City General Hospital, Japan.

Epilepsia
|April 29, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolation and characterization of the groES and groEL genes of Bacillus subtilis Marburg.

Bioscience, biotechnology, and biochemistry·1992
Same author

Distribution of filipin-sterol complexes in the bloodstream form of Trypanosoma brucei gambiense.

Journal of electron microscopy·1992
Same author

Pathology of chemically induced chronic active hepatitis in mice.

Experimental and molecular pathology·1992
Same author

Establishment and maintenance of bovine leukosis virus-free farm.

The Kitasato archives of experimental medicine·1992
Same author

Molecular weight-dependent lymphatic transfer of exogenous macromolecules from large intestine of renal insufficiency rats.

Pharmaceutical research·1992
Same author

Freeze-fracture study of the site of attachment of Cryptosporidium muris in gastric glands.

The Journal of protozoology·1992
Same journal

Semiology of functional/dissociative seizures in idiopathic generalized epilepsy: An inpatient video-electroencephalographic study.

Epilepsia·2026
Same journal

Perineuronal net abnormalities in epileptic human tissue.

Epilepsia·2026
Same journal

Cortical stimulation reveals effective disconnection of the epileptogenic network at seizure onset.

Epilepsia·2026
Same journal

Anterior cingulate cortex neuron subtypes differentially regulate seizures.

Epilepsia·2026
Same journal

Ultrafast oscillations in the human brain and their functional significance.

Epilepsia·2026
Same journal

Magnetoencephalographic source imaging improves localization of the epileptogenic zone in multimodal imaging evaluation.

Epilepsia·2026
See all related articles

Acute peripheral neuropathy is a rare side effect of phenytoin (PHT). This case report details an extremely rare instance of PHT-induced peripheral neuropathy developing within hours of initial administration.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Clinical Neurology

Background:

  • Peripheral neuropathy is a known, albeit rare, adverse effect of phenytoin (PHT) therapy.
  • Typically, PHT-induced peripheral neuropathy manifests after prolonged drug exposure.

Observation:

  • An 18-year-old female patient presented with epilepsy requiring phenytoin administration.
  • Within hours of receiving PHT, she developed distal lower extremity paresthesia and motor weakness, with absent Achilles reflexes.

Findings:

  • Electrophysiological studies indicated reduced sensory nerve conduction velocity and prolonged distal latencies in the lower extremities.
  • Symptoms resolved, and electrophysiological parameters normalized after PHT discontinuation.

Implications:

Related Experiment Videos

  • This case highlights an extremely rare acute onset of PHT-induced peripheral neuropathy, occurring hours after initial PHT administration.
  • Clinicians should maintain vigilance for acute peripheral neuropathy as a potential adverse effect of phenytoin, even with short-term use.