Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How long should first-line chemotherapy continue?

K Bertelsen1, S Grenman, G J Rustin

  • 1Department of Oncology, Odense University Hospital, Denmark. kamma bertelsen@ouh.dk

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|April 29, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Value of <sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Response Evaluation after Primary Treatment of Advanced Epithelial Ovarian Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2018
Same author

Association of asymptomatic bacterial vaginosis with persistence of female genital human papillomavirus infection.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2017
Same author

The presence of human papillomavirus (HPV) in placenta and/or cord blood might result in Th2 polarization.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2017
Same author

Genotype-specific concordance of oral and genital human papillomavirus infections among marital couples is low.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2016
Same author

Oral human papillomavirus infection in men might contribute to HPV serology.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2014
Same author

Effects of JNJ-40929837, a leukotriene A4 hydrolase inhibitor, in a bronchial allergen challenge model of asthma.

Pulmonary pharmacology & therapeutics·2014

For advanced ovarian cancer, evidence suggests 6 cycles of chemotherapy are optimal. Studies comparing 6 cycles to longer durations found no added benefit, establishing 6 cycles as the current standard.

Area of Science:

  • Oncology
  • Gynecologic Oncology
  • Clinical Trials

Background:

  • Optimal duration of first-line chemotherapy for advanced ovarian cancer remains under-documented.
  • Existing randomized trials comparing 5-6 cycles with 8-12 cycles have not demonstrated benefits beyond 6 cycles.

Purpose of the Study:

  • To evaluate the optimal number of chemotherapy cycles for advanced ovarian cancer.
  • To determine if chemotherapy duration beyond 6 cycles provides additional clinical benefit.

Main Methods:

  • Review of three randomized trials comparing different durations of first-line chemotherapy.
  • Analysis of outcomes based on chemotherapy cycle number and cumulative dose.

Main Results:

  • No significant benefit was observed for chemotherapy regimens exceeding 6 cycles.

Related Experiment Videos

  • Current data, based on non-taxane regimens, supports 6 cycles as the standard.
  • No trials have shown benefit for high-dose intensity chemotherapy over a shorter period compared to standard duration.

    • Conclusions:

    • Six cycles of chemotherapy are currently considered the standard for advanced ovarian cancer based on available evidence.
    • The optimal number of cycles may differ with taxane-containing regimens, requiring further investigation.
    • The relationship between chemotherapy cycle number, cumulative dose, and treatment response needs further clarification.