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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Internalization of growth factor-receptor complexes under the influence of antibodies initiates cell apoptosis in

V A Lavrovsky1, A S Chagin, T N Subkhankulova

  • 1Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, Novosibirsk/Russia. vadim@mailhost.bionet.nsc.ru

European Journal of Cell Biology
|April 29, 1999
PubMed

Antibodies against growth factors like IGF1, IGF2, aFGF, bFGF and, to a certain extent, TGF alpha and EGF were shown to cause apoptosis of normal and tumorigenic cells while apoptotic cell death could be prevented neither by single growth factors nor by serum. Antibodies to growth factors caused apoptosis by interacting with growth factors bound to their receptors on the cell surface. The phenomenon is likely to be associated with active internalization of growth factor receptors loaded with ligands. Apparently these activated receptors are essential for cell survival and their disappearance from the cell surface initiates apoptosis.

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