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Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists
1Biotechnology Research Division, Korea Research Institute of Bioscience and Biotechnology, Taejon.
Biological & Pharmaceutical Bulletin
|April 29, 1999
Abstract:
We studied the structure-activity relationships of lignans from Schisandra chinensis and their derivatives as platelet activating factor (PAF) antagonists. Strong activity was shown in lignans without an ester group at C-6, a hydroxyl group at C-7 or a methylene dioxy moiety and with an R-biphenyl configuration. 6(7)-Dehydroschisandrol A, a derivative of schisandrol A, showed the highest activity (IC50, 2.1x10(-6) M) in this study.