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Related Experiment Videos

A small, physiological electric field orients cell division.

M Zhao1, J V Forrester, C D McCaig

  • 1Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland.

Proceedings of the National Academy of Sciences of the United States of America
|April 29, 1999
PubMed
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Applied electric fields (EFs) direct cell division orientation. Human corneal epithelial cells divided with cleavage planes perpendicular to direct-current EFs, suggesting physiological EFs regulate cell positioning in development and healing.

Area of Science:

  • Cell Biology
  • Bioelectricity
  • Developmental Biology

Background:

  • Cell division orientation is crucial for tissue development and repair.
  • Physiological electric fields (EFs) are present during various in vivo processes like embryonic morphogenesis and wound healing.
  • The role of endogenous EFs in directing cell division remains largely unexplored.

Purpose of the Study:

  • To investigate the effect of applied electric fields on the orientation of cell division.
  • To determine if direct-current physiological electric fields can influence the cleavage plane of dividing cells.
  • To explore the potential role of endogenous electric fields in regulating cell division during biological processes.

Main Methods:

  • Cultured human corneal epithelial cells were utilized.

Related Experiment Videos

  • Cells were exposed to a direct-current electric field (EF) of physiological magnitude.
  • The orientation of the cell cleavage plane relative to the EF vector was observed during cell division.

    • Main Results:

    • Applied electric fields were found to direct the orientation of cell division.
    • The majority of dividing cells exhibited a cleavage plane perpendicular to the applied EF vector.
    • This indicates a direct influence of electric fields on the spatial organization of cell division.

    Conclusions:

    • Small, applied electric fields can orient cell division.
    • Endogenous physiological electric fields may regulate the axis of cell division in vivo.
    • This regulation by electric fields could be significant in processes such as embryonic development, differentiation, wound healing, and tumor formation.